Scientist / Chemist

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to life-changing medicines for people with serious diseases — often with limited or no We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers […]

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to
life-changing medicines for people with serious diseases — often with limited or no
We have a diverse portfolio of marketed medicines, including leading
therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments.
Our patient-focused and science-driven approach powers pioneering research and development
advancements across our robust pipeline of innovative therapeutics in oncology and
neuroscience. Jazz is headquartered in Dublin, Ireland with research and development
laboratories, manufacturing facilities and employees in multiple countries committed to
serving patients worldwide. We are looking for dynamic, creative, and talented computational chemist to join our expanding Discovery & Medicinal Chemistry Department. Reporting to the Director of Medicinal Chemistry, you will apply your expertise, leadership and guidance to discover and develop novel small-molecule therapeutic agents. You will be working within a patient-focused, science-driven, and multi-disciplinary biopharmaceutical environment, covering all stages of the drug discovery process. You will collaborate with scientists from other disciplines within Jazz Pharmaceuticals and with external collaborators to build an innovative portfolio of therapeutics across our exciting and growing oncology and neuroscience pipelines. Working at the forefront of drug discovery you will advance projects from target selection to preclinical drug candidates and FiH trials, and contribute to the growth of the medicinal chemistry team.
Collaborate effectively with other departments and functions to advance research discovery projects expeditiously from hit identification to high quality preclinical candidates.
Design, lead and drive computational studies on projects throughout the several discovery phases and ensure execution on agreed deliverables.
Opportunities to lead or co-lead projects in addition to drive discipline-specific endeavours.
Set the vision and strategy for computational chemistry.
Foster innovative thinking in all areas of departmental activities, with a particular focus on computational and medicinal chemistry.
Contribute to the writing of patent applications, scientific publications, and internal reports.
Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies.
Undertake ongoing professional development by attending relevant training and conferences.
MSc/PhD in a relevant scientific discipline (Pharmaceutical Sciences, Chemistry, Computational Chemistry) with a solid foundation in molecular modelling built in a pharma/biotech/CRO setting.
Expert knowledge in CADD software packages and modern molecular modelling techniques.
Mastery of all the theoretical and practical principles of medicinal chemistry and drug design.
In depth understanding of multi-parameter optimization and ability to integrate disease biology, ADME/DMPK and toxicology data to solve complex drug discovery problems.
Excellent leadership, management, organizational and team-working skills, and a talent to deliver project milestones within the expected time frame.
Demonstrated track record of scientific publications.
Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.
The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation.